Cardiac Innate Immunity

 Cardiac Innate Immunity
Work team
Cardiac Innate Immunity
Cardiac Innate Immunity
Cardiac Innate Immunity

Research Projects


Ponce NE, Sanmarco LM, Eberhardt N, Garcia MC, Rivarola W, Cano RC, Aoki MP. CD73 inhibition shifts cardiac macrophage polarization toward a microbicidal phenotype and ameliorates the outcome of experimental Chagas cardiomyopathy. Journal of Immunology (2016) Aug 1; 197(3):814-23. doi: 10.4049/jimmunol.1600371.

Garcia, MC; Ponce, NE; Sanmarco, LM; Manzo, RH; Jimenez-Kairuz, AF; Aoki, MP. Clomipramine and Benznidazole act synergistically and ameliorate the outcome of experimental Chagas disease: In vivo and in vitro assessments. Antimicrobial Agents and Chemotherapy (2016) Vol 60; Issue 6; doi: 10.1128/AAC.00404-16.

Cabalén ME, Cabral MF, Sanmarco LM, Andrada MC, Onofrio LI, Ponce NE, Aoki MP, Gea S, Cano RC. Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity mode. Oncotarget (2016) Feb 23. doi: 10.18632/oncotarget.7630

Arocena AR, Onofrio LI, Pellegrini AV, Carrera Silva AE, Paroli A, Cano RC, Aoki MP, Gea S. Myeloid-derived suppressor cells are key players in the resolution of inflammation during a model of acute infection. Eur J Immunol (2014) Jan;44(1):184-94. doi: 10.1002/eji.201343606.

Ponce NE; Carrera-Silva EA; Pellegrini AV, Cazorla SI, Malchiodi LE; Lima AP; S Gea; Aoki MP. Trypanosoma cruzi, the causative agent of Chagas disease, modulates IL6-induced STAT3 phosphorylation via gp-130 cleavage in different host cells. Biochimica et Biophysica Acta-Molecular Basis of Disease (2013) 1832 485-494. doi: 10.1016/j.bbadis.2012.12.003.

Ponce NE; Cano RC; Carrera-Silva EA; Lima AP; Gea S; Aoki MP. Toll-like receptor-2 and Interleukine-6 mediate cardiomyocyte protection from apoptosis during Trypanosoma cruzi murine Infection. Medical Microbiology and Immunology (2012); 201: 145-155. doi: 10.1007/s00430-011-0216-z.

Aoki MP, Carrera-Silva EA; Cuervo H, Fresno M, Gironés N, Gea S. Non-immune cells contribute to cross-talk between immune cells and inflammatory mediators in the innate response to Trypanosoma cruzi infection. J Parasitol Res (2012); 2012:737324. doi: 10.1155/2012/737324.

Pellegrini A, Carrera-Silva EA, Arocena A, Cano RC, Aoki MP, Gea S. Trypanosoma cruzi antigen immunization induces a higher B cell survival in BALB/c mice, a susceptible strain, compared to C57BL/6 B lymphocytes, a resistant strain to cardiac autoimmunity. Med Microbiol Immunol (2011) Nov;200(4):209-18. doi: 10.1007/s00430-011-0192-3

Carrera-Silva EA, Guiñazu N, Pellegrini A, Cano RC, Arocena A, Aoki MP, Gea S. Importance of TLR2 on hepatic immune and non-immune cells to attenuate the strong inflammatory liver response during Trypanosoma cruzi acute infection. PLoS Negl Trop Dis (2010) Nov 2;4(11):e863. doi: 10.1371/journal.pntd.0000863.

Carrera-Silva EA, Cano RC, Guiñazú N, Aoki MP, Pellegrini A, Gea S. TLR2, TLR4 and TLR9 are differentially modulated in liver lethally injured from BALB/c and C57BL/6 mice during Trypanosoma cruzi acute infection. Mol Immunol (2008) Aug;45(13):3580-8. doi: 10.1016/j.molimm.2008.05.004.

Cuervo H, Pineda MA, Aoki MP, Gea S, Fresno M, Gironès N. Analysis of classical and alternative activation in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages. The Journal of Infectious Diseases (2008) 197(12):1772-82. Doi: 10.1086/529527.

Savino W, Villa-Verde SM, Mendes-da-Cruz D, Silva-Monteiro E, Perez AR, Aoki MP, Bottasso O, Guiñazú N, Silva-Barbosa SD and Gea S. Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi. Cytokine & Growth Factor Reviews (2007) 18: 107-124. Revisión. Doi:10.1016/j.cytogfr.2007.01.010.

Aoki MP, Cano RC, Pellegrini AV, Tanos T, Guinazu NL, Coso OA and Gea S. Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein. Microbes Infect (2006) Jun;8(7):1723-31.

Aoki MP, Guiñazú NL, Pellegrini AV, Gotoh T, Masih DT, Gea S. Cruzipain, a major Trypanosoma cruzi antigen, promotes arginase-2 expression and survival of neonatal mouse cardiomyocytes. Am J Physiol Cell Physiol (2004) Feb;286(2):C206-12.