Mechanisms of Thyroid Hormone Action

Work team
Work team
Work team
Work team
Mechanisms of Thyroid Hormone Action
Mechanisms of Thyroid Hormone Action
Mechanisms of Thyroid Hormone Action
Mechanisms of Thyroid Hormone Action
Mechanisms of Thyroid Hormone Action

Research projects

Main publications of the research group

1. Alamino VA, Montesinos MM, Rabinovich GA, Pellizas CG. “The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity”. Oncoimmunology 2016 (en prensa).

2. Alamino V, Mascanfroni I, Montesinos M, Gigena N, Donadio A, Blidner A, Militich S, Masini-Repiso M, Rabinovich G. Pellizas C. “Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to thyroid hormone receptor beta”. Cancer Research 2015, 75(7):1265-74.

3. Racca MA, Novoa PA, Rodríguez I, Della Vedova AB, Pellizas CG, Demarchi M, Donadio AC. Renal dysfunction and intragraft proMMP9 activity in renal transplant recipients with interstitial fibrosis and tubular atrophy. Transpl Int. 2015 Jan;28(1):71-8. doi: 10.1111/tri.12445. Epub 2014 Oct 2.

4. Fozzatti L, Kim DW, Park JW, Willingham MC, Hollenberg AN, Cheng SY. Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor α. Proc Natl Acad Sci U S A. 2013, 110:7850-5.

5. Fozzatti L, Park JW, Zhao L, Willingham MC, Cheng SY. Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer. PLoS One. 2013, 8:e67954.

6. Fozzatti L, Lu C, Kim DW, Park JW, Astapova I, Gavrilova O, Willingham MC, Hollenberg AN, Cheng SY. Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1). Proc Natl Acad Sci U S A. 2011, 108:17462-7.

7. Montesinos M, Alamino V, Mascanfroni I, Susperreguy S, Gigena N, Masini-Repiso A, Rabinovich G, Pellizas C. Dexamethasone counteracts the immunostimulary effects of triiodothyronine (T3) on dendritic cells. Steroids 2012, 77:67–76.

8. Susperreguy S, Muñoz L, Tkalenko NY, Mascanfroni ID, Alamino VA, Montesinos MM, Masini-Repiso AM, Miras MB, Pellizas CG. Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action. Clinical Endocrinology (Oxf). 2011, 74:346-353.

9. Fozzatti L, Lu C, Kim DW, Cheng SY. Differential recruitment of nuclear coregulators directs the isoform-dependent action of mutant thyroid hormone receptors. Mol Endocrinol. 2011, 25:908-21.

10. Mascanfroni ID, Montesinos MM, Alamino V, Susperreguy S, Nicola J, Ilarregui J, Masini-Repiso A, Rabinovich GA & Pellizas CG. “Nuclear factor NF-kB-dependent thyroid hormone receptor β1-expression controls dendritic cell function via AKT signaling". Journal of Biological Chemistry 2010, 285 (13): 9569-9582.

11. Donadio AC, Remedi MM, Susperreguy S, Frede S, Gilardoni MB, Tang Y, Pellizas CG, Yan L. “Extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinases (MMPs) as regulators of tumor-host interaction in a spontaneous metastasis model in rats”. Histochem Cell Biol. 2008, 130(6):1155-64.

12. Mascanfroni I, Montesinos M, Susperreguy S, Cervi L, , Ilarregui J, Ramseyer VD, Masini-Repiso AM, Targovnik H, Rabinovich GA & Pellizas CG. Control of dendritic cell maturation and function by triiodothyronine (T3)”. FASEB Journal 2008, 22:1032-42.

13. Susperreguy S, Miras MB, Montesinos MM, Mascanfroni I, Muñoz L, Sobrero G, Silvano L, Masini-Repiso A, Coleoni AH, Targovnik HM, Pellizas CG. Growth hormone treatment reduces peripheral thyroid hormone action in girls with Turner Syndrome. Clinical Endocrinology 2007, 67:629-636.

14. Fozzatti L, Vélez L, Lucero A, Incola J, Mació A, Pellizas CG, Roth G, Masini-Repiso A. Endogenous thyrocyte-produced nitric oxide inhibits iodide uptake and thyroid specific gene expresión in FRTL-5 cells. Journal of Endocrinology 2007, 192: 627–637.

15. Montesinos M, Pellizas CG, Vélez M, Susperreguy S, Masini-Repiso A & Coleoni AH. Thyroid hormone receptor β1 gene expression is increased by dexamethasone at transcriptional level in rat liver. Life Science 2006, 78: 2584–2594.

16. Donadio AC, Lobo C, Tosina M, de la Rosa V, Martín-Rufián M, Campos-Sandoval JA, Matés JM, Márquez J, Alonso FJ, Segura JA. Antisense glutaminase inhibition modifies the O-GlcNAc pattern and flux through the hexosamine pathway in breast cancer cells. J Cell Biochem. 2008, 103:800-11.