Molecular mechanisms involved in the physiology and pathology of the thyroid gland

Work team. From left to right: Dr. Nicola,  Dra. Masini-Repiso y Bioq. Peyret.
Work team. From left to right: Bioq. Peyret, Lic. Martín y Dr. Nicola.
Molecular mechanisms involved in the physiology and pathology of the thyroid gland
Molecular mechanisms involved in the physiology and pathology of the thyroid gland
Molecular mechanisms involved in the physiology and pathology of the thyroid gland
Molecular mechanisms involved in the physiology and pathology of the thyroid gland
Molecular mechanisms involved in the physiology and pathology of the thyroid gland

Research projects

PARTICIPACIÓN DEL RECEPTOR TOLL-LIKE 4 (TLR4) EN EL PROCESO DE CARCINOGÉNESIS TIROIDEA.

MECANISMOS MOLECULARES INVOLUCRADOS EN EL TRÁFICO DEL TRANSPORTADOR DE SODIO/IODURO A LA MEMBRANA PLASMÁTICA EN LA CÉLULA FOLICULAR TIROIDEA.

IDENTIFICACIÓN DE DEFECTOS GENÉTICOS QUE CONDUCEN AL HIPOTIROIDISMO CONGÉNITO COMO CONSECUENCIA DE UNA ACUMULACIÓN DEFICIENTE DE IODURO EN LA CÉLULA FOLICULAR TIROIDEA.

DESARROLLO DE METODOLOGÍAS DE DIAGNÓSTICO MOLECULAR PARA LA DETECCIÓN DE ONCOGENES EN MATERIAL PROCEDENTE DE PUNCIÓN ASPIRATIVA CON AGUJA FINA DE NÓDULOS TIROIDEOS.

Selected publications (since 2010)

Ferrandino G, Nicola JP, Sánchez YE, Echeverria I, Liu Y, Amzel LM, Carrasco N. (2016) “Na+ coordination at the Na2 site of the Na+/I- symporter (NIS)” Proc Natl Acad Sci USA (In press).

Montesinos MM, Nicola JP, Nazar M, Peyret V, Lucero AM, Pellizas CG, Masini-Repiso AM. (2016) “Nitric oxide-repressed Forkhead Factor FOXE1 expression is involved in the inhibition of TSH-induced thyroid peroxidase levels” Mol Cell Endocrinol 420:105-15.

Nicola JP, Peyret V, Nazar M, Romero JM, Lucero AM, Montesinos MM, Bocco JL, Pellizas CG, Masini-Repiso AM. (2015) “NF-κB p65 S-nitrosylation inhibits TSH-induced Na+/I- Symporter expression” Endocrinology 156(12):4741-54.

Alamino VA, Mascanfroni ID, Montesinos MM, Gigena N, Donadio AC, Blidner AG, Milotich SI, Cheng SY, Masini-Repiso AM, Rabinovich GA, Pellizas CG. (2015) “Antitumor Responses Stimulated by Dendritic Cells Are Improved by Triiodothyronine Binding to the Thyroid Hormone Receptor β”. Cancer Res. 75(7):1265-74

Nicola JP, Reyna-Neyra A, Saenger P, Rodriguez-Buritica D, Gamez JD, Muzumdar R, Amzel LM, Carrasco N. (2015) “The sodium/iodide symporter mutant V270E causes stunted growth but no cognitive deficiency” J Clin Endocrinol Metab. 100(10):E1353-61.

Nicola JP, Carrasco N, Amzel LM. (2014) “Physiological sodium concentrations enhance the iodide affinity of the Na+/I- symporter (NIS)”. Nature Commun. 5:3948.

Paroder V, Nicola JP, Ginter CS, Carrasco N. (2013) “The Iodide Transport Defect-Causing Mutation R124H: a δ-amino group at position 124 is critical for maturation and trafficking of the Na+/I- symporter (NIS)”. J Cell Science 126(15): 3305-3313.

Li W, Nicola JP, Amzel LM, Carrasco N. (2013) “Asn441 plays a key role in folding and function of the Na+/I- symporter (NIS)”. FASEB J 27(8):3229-3238.

Nicola JP, Reyna-Neyra A, Carrasco N, Masini-Repiso AM. (2012). “Dietary iodide regulates intestinal Na+/I- symporter (NIS) expression”. J Physiol 590(23): 6013-6026.

Nazar M, Nicola JP, Vélez ML, Pellizas CG, Masini-Repiso AM. (2012). “Thyroid peroxidase gene expression is induced by lipopolysaccharide involving Nuclear factor (NF)-κB p65 subunit phosphorylation”. Endocrinology 153(12):6114-6125.

Paroder M, Maestas MJ, Dohán O, Nicola JP, Reyna-Neyra A, Follenzi A, Dadachova E, Eskandari S, Amzel M, Carrasco N. (2011). “Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS)”. Proc Natl Acad Sci USA 108(44):17933-17938.

Nicola JP, Nazar M, Serrano-Nascimento C, Goulart-Silva F, Sobrero G, Testa G, Nunes MT, Muñoz L, Miras M, Masini-Repiso AM. (2011). “Iodide transport defect: functional characterization of a novel mutation in the Na+/I- symporter 5'-untranslated region in a patient with congenital hypothyroidism”. J Clin Endocrinol Metab. 96(7):E1100–E1107.

Nicola JP, Nazar M, Mascanfroni ID, Pellizas CG, Masini-Repiso AM. (2010). “NF-kappaB p65 subunit mediates lipopolysaccharide-induced Na+/I- symporter gene expression by involving functional interaction with the paired domain transcription factor Pax8”. Mol Endocrinol 24(9):1846-1862.

Mascanfroni ID, Montesinos MM, Alamino VA, Susperreguy S, Nicola JP, Ilarregui JM, Masini-Repiso AM, Rabinovich GA, Pellizas CG. (2010). “Nuclear factor (NF)-κB-dependent thyroid hormone receptor β1-expression controls dendritic cell function via AKT signaling”. J Biol Chem 285(13):9569-9582.