Onconesis and tumor suppression mechanisms

Work team
Work team
Onconesis and tumor suppression mechanisms
Onconesis and tumor suppression mechanisms
Onconesis and tumor suppression mechanisms
Onconesis and tumor suppression mechanisms

Research Projects

“FunctionalAnalysis of the Transcription Factor KLF6 in the Control of Cell Proliferation and Oncogenesis”

The transcription factor KLF6 (Krüppel-likeFactor6) was identified in our laboratory as a regulator of expression of genes encoding PSG proteins (Pregnancy-Specific Glycoproteins).

Mutations or expression defects in klf6 gene are associated with the development of different types of cancer in humans, suggesting a role of KLF6 as tumor suppressor.

Results from our group demonstrated a new mechanism of KLF6 in reducing cell proliferation involving the degradation of the proto-oncoprotein c-Jun. Furthermore, KLF6 is capable of reducing tumor generation in vivo triggered by mutated Ras oncogene (mutations in Ras oncogene are present in more than 30% of human cancers). These results correlate with cell cycle arrest in G1 through increased expression of p21(CIPI/WAF1).In this context, neither the induction of p53 nor apoptotic cell death were detected. Interestingly, this cytostatic response of KLF6 correlates directly with apoptosis resistance caused by DNA-damaging chemotherapy drugs used in cancer treatment. Then, demonstrating that KLF6 has the ability to hinder Ras-induced tumorigenesis, which involved a marked arrest in cell cycle progression, supports a relevant role of KLF6 as a tumor suppressor.

Publications

Dr. Bocco has published numerous peer-reviewed papers in prestigious journals. To see a detailed list of publications, please go to:

https://scholar.google.com.ar/