Immunity to infections and cancer

Investigation Group
Jimena Tosello Boari
Cintia Araujo Furlán
Constanza Rodríguez

Research Project

Our group is mainly focused to investigate the mechanisms involved in the development of effector and regulatory immune response during infections. In these projects, we work in close collaboration with groups led by Drs. Adriana Gruppi and Carolina Montes.

Using the experimental infection with Trypanosoma cruzi as a model, we study basic immune mechanisms involved in protective and pathogenic responses. At present, we are interested in expanding the study of immunological mechanisms discovered in our laboratory to other models of chronic diseases such as cancer and autoimmunity. While our laboratory has a strong imprinting in basic research, one of our ongoing goals is to translate our findings from animal models into clinical research.

Specifically, the projects currently underway are:

  • Study of the role of cytokines that signal via IL-17RA in the development of immunity CD8 + T cells against Trypanosoma cruzi
  • Study of the contribution of regulatory T cell response in the progression of the infection with Trypanosoma cruzi
  • Study of the role of cytokines IL-17 family in the induction of antitumor cytotoxic response and tumor progression

Publications (Selected)

  1. The regulatory role of B cells in autoimmunity, infections and cancer: perspectives beyond IL10 production. Gorosito Serran M, Fiocca Vernengo F, Beccaria C, Acosta Rodriguez EV, Montes CL, Gruppi A. FEBS Lett. 2015 Sep 28. pii: S0014-5793(15)00834-0. doi: 10.1016/j.febslet.2015.08.048.
  2. Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L. Ramello MC, Tosello Boari J, Canale F, Mena H, Negrotto S, Gastman B, Gruppi A, Acosta Rodríguez EV; Montes CL. Cell Death & Disease. 2014 Nov 6;5:e1507. doi: 10.1038/cddis.2014.451. FI: 5,177

  3. Trypanosoma cruzi trans-sialidase initiates an ROR-t/AHR independent program leading to IL-17 production by activated B cells. Daniela A Bermejo, Shaun W Jackson, Melisa Gorosito-Serran, Eva V Acosta-Rodriguez, Maria C Amezcua-Vesely, Blythe D Sather, Akhilesh K. Singh, Socheath Khim, Juan Mucci, Denny Liggitt, Oscar Campetella, Mohamed Oukka, Adriana Gruppi, David J Rawlings. Nature Immunology. 2013 May:14(5):415-522. FI 24,973

  4. Brucella abortus-infected macrophages modulate T lymphocytes to promote osteoclastogenesis via IL-17. Guillermo H. Giambartolomei, Romina Scian, Eva Acosta-Rodríguez, Carlos A. Fossati, M. Victoria Delpino. American Journal of Pathology. 2012 Sep;181(3):887-96. FI: 5,571

  5. IL-17RA signaling reduces inflammation and mortality during Trypanosoma cruzi infection in mice by recruiting suppressive IL-10-producing neutrophils. J Tosello Boari, MC Amezcua Vesely, DA Bermejo, MC Ramello, CL Montes, H Cejas, A Gruppi, EV Acosta Rodríguez. Plos Pathogens. 2012 Apr:8(4): e1002658. FI: 9,127.

  6. FcgammaRIIb and BAFF differentially regulate peritoneal B1 cell survival. MC Amezcua Vesely, M Schwartz, DA Bermejo, CL Montes, A Kalergis, D Rawlings, EV Acosta-Rodríguez, A Gruppi. Journal of Immunolology. 2012 May 15;188(10):4792-800. Epub 2012 Apr 18. FI: 5,745.

  7. B cell response during protozoan parasite infections. MC Amezcua Vesely,  DA Bermejo, CL Montes, EV Acosta-Rodríguez, A Gruppi. Journal of Parasitology Research. 2012:362131. Epub 2012 Jan 23

  8. 3-Hydroxy Kynurenine treatment controls T. cruzi replication and the inflammatory pathology preventing the clinical symptoms of Chronic Chagas disease. CP Knubel, FF Martínez, EV Acosta Rodríguez, A Altamirano, HW Rivarola, CD Lujan, RE Fretes, L Cervi, CC. Motran. PLoS One. 2011;6(10):e26550. FI: 4,411.

  9. Trypanosoma cruzi infection induces a massive extrafollicular and follicular splenic B cell response which is a high source of non-parasite specific antibodies. DA Bermejo, MC Amezcua-Vesely, M Kahn, EV Acosta-Rodríguez, CL Montes, MC Merino, KM Toellner, E Mohr, D Taylor, A Cunningham, A Gruppi. Immunology 2011 Jan;132(1):123-33.  FI:3,432

  10. BAFF mediates splenic B cell response and antibody production in experimental Chagas disease. DA Bermejo, MC Amezcua-Vesely, CL Montes, MC Merino, H Cejas,  EV Acosta-Rodríguez, A Gruppi. PLOS Neglected Tropical Diseases. 2010 May 4;4(5):e679. FI:4,172

  11. Prostaglandin E2 enhances Th17 responses by differentially modulating the production of IL-17 and IFN-g by purified memory CD4+ T cells. G Napolitani*, EV Acosta-Rodríguez*, A Lanzavecchia, F Sallusto. *igual contribución al manuscrito. European Journal of Immunology. 2009 May;39(5):1301-12. FI: 4,865.

  12. Polyclonal B cell activation in infections: infectious agents’ devilry or defense mechanism of the host? Montes CL, Acosta-Rodriguez EV, Merino MC, Bermejo DA, Gruppi A. Journal of Leukocyte Biology. 2007 Nov;82(5):1027-32. FI: 4,128.

  13. Interleukins 1beta and 6 but not transforming growth factor-beta are critical cytokines for induction of human Th17 cells. EV Acosta-Rodríguez, G Napolitani, A Lanzavecchia, F Sallusto. Nature Immunology. 2007. Sep;8(9):942-9. FI: 26,218.

  14. Trypanosoma cruzi infection beats the B cell compartment favoring parasite establishment. Can we strike first? EV Acosta Rodriguez, EI Zuñiga, CL Montes, MC Merino, DA Bermejo, MC Amezcua Vesely, CC Motran, A Gruppi. Scandinavian Journal of Immunology. 2007. Aug-Sep;66(2-3):137-42.

  15. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. EV Acosta-Rodríguez, L Rivino, J Geginat, D Jarrossay, M Gattorno, A Lanzavecchia, F Sallusto, G Napolitani. Nature Immunology. 2007. Jun 8(6):639-46. FI: 26,218.

  16. Cytokines and chemokines shaping the B-cell compartment. EV Acosta-Rodriguez, MC Merino, CL Montes, CC Motrán and A Gruppi. Cytokine and Growth Factor Reviews. 2007. Feb-Apr;18(1-2):73-83.

  17. BAFF and LPS cooperate to induce B cells to become susceptible to CD95/Fas-mediated cell death. EV Acosta-Rodríguez, A Craxton, DW Hendricks, MC Merino, CL Montes, EA Clark and A Gruppi. European Journal of Immunology. 2007. Apr;37(4):990-1000.

  18. Depletion of immature B cells during Trypanosoma cruzi infection: involvement of myeloid cells and cyclooxigenase pathway. E. Zúñiga, EV Acosta-Rodríguez, MC Merino, CL Montes and A Gruppi. European Journal of Immunology. 2005. Jun;35(6):1849-58.

  19. Galectin-3 Mediates Interleukin-4-Induced Survival and Differentiation of B Cells. Functional Cross-talk and Implications during Trypanosoma cruzi Infection. EV Acosta-Rodríguez, E Zúñiga, CL Montes, CC Motrán, FT Liu, GA Rabinovich y A Gruppi. Journal of Immunology. 2004. Jan 1;172(1):493-502. FI: 6,486.

  20. Interleukin-4 bias differentiation of Trypanosoma cruzi-infected mice B cells to the memory pathway and restrains their fratricide: Fas ligand down-regulation and class II-transactivator up-regulation. EV Acosta-Rodríguez, E Zúñiga, CL Montes y A Gruppi. Journal of Leukocyte Biology. 2003. Jan;73(1):127-36. FI: 4,18.