Vaccine Laboratory

 Vaccine Laboratory

Investigation project


Sánchez Vallecillo MF, Minguito de la Escalera MM, Aguirre MV, Ullio Gamboa GV, Palma SD, González-Cintado L, Chiodetti AL, Soldano G, Morón G, Allemandi DA, Ardavín C, Pistoresi-Palencia MC, Maletto B. A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein. J Control Release. 28; 214:12-22. 2015.

Sánchez Vallecillo MF, Ullio Gamboa GV, Palma SD, Harman MF, Chiodetti AL, Morón G, Allemandi DA, Pistoresi-Palencia MC, Maletto B. Adjuvant activity of CpG-ODN formulated as a liquid crystal. Biomaterials. 35(8):2529-42. 2014.

María F. Harman, Romina P. Ranocchia, Carolina V. Gorlino, María F. Sánchez Vallecillo, Sofía D. Castell, María I. Crespo, Belkys Maletto, Gabriel Morón, María C. Pistoresi-Palencia. Expansion of myeloid-derived suppressor cells with arginase activity lasts longer in aged than in young mice after CpG-ODN plus IFA treatment. Oncotarget 6 (15): 13448-13461. 2015.

Zacca ER, Crespo MI, Acland RP, Roselli E, Núñez NG, Maccioni M, Maletto BA, Pistoresi-Palencia MC, Morón G. Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8+ T Cells upon Stimulation with a TLR7 Ligand. PLoS One.10 (10):e0140672. 2015.

Carolina V. Gorlino; Romina P. Ranocchia; María F. Harman; Iris A. García; María I. Crespo; Gabriel Morón; Belkys Maletto; María C. Pistoresi-Palencia. Neutrophils exhibit differential requirements for homing molecules in their lymphatic and blood trafficking into draining lymph nodes. J Immunol. 193(4):1966-74. 2014.

Cuggino JC, Contreras CB, Jimenez-Kairuz A, Maletto B, Alvarez Igarzabal CI. Novel Poly(NIPA-co-AAc) Functional Hydrogels with Potential Application in Drug Controlled Release. Mol Pharm. 11(7):2239-49. 2014.

Crespo MI, Zacca ER, Núñez NG, Ranocchia RP, Maccioni M, Maletto B, Pistoresi-Palencia MC, Morón G. TLR7 Triggering with Polyuridylic Acid Promotes Cross-Presentation in CD8α+ Conventional Dendritic Cells by Enhancing Antigen Preservation and MHC Class I Antigen Permanence on the Dendritic Cell Surface. J Immunol. 190(3):948-60. 2013.

R. Ranocchia, C. Gorlino, M.I. Crespo, F. Harman, M. Liscovsky, G. Morón, B. Maletto, M. C. Pistoresi-Palencia. Arginase-dependent suppression by CpG-ODN plus IFA-induced splenic myeloid CD11b+ Gr1+ cells. Immunol Cell Biology 90(7):710-21. 2012.

Liscovsky MV, Ranocchia RP, Alignani DO, Gorlino CV, Morón G, Maletto B, Pistoresi-Palencia MC. CpG-ODN+IFN-γ confer pro- and anti-inflammatory properties to peritoneal macrophages in aged mice. Exp Gerontol. 46(6):462-7. 2011.

Rivero MR, Vranych CV, Bisbal M, Maletto Belkys, Ropolo AS, Touz MC. Adaptor Protein 2 Regulates Receptor-Mediated Endocytosis and Cyst Formatio-n in Giardia lamblia. Biochem J Cells. 428:33. 2010.

M. Liscovsky, R Ranocchia, C. Gorlino, D. Alignani, G. Moron, B. Maletto, M. C. Pistoresi-Palencia. IFN-g priming is involved in the activation of arginase by oligodeoxinucleotides containing CpG in murine macrophages. Immunology 128 (1 suppl), e159-169. 2009.

B. Maletto, A. Rópolo, D. Alignani, M. Liscovsky, R Ranocchia, G. Moron, M. C. Pistoresi-Palencia. Presence of neutrophil-bearing antigen in lymphoid organs of immune mice. Blood 108:3094. 2006.

C. Montes, B. Maletto, E. Acosta, A. Gruppi, M. C. Pistoresi-Palencia. B cells from aged mice exibit reduced apoptosis upon BCR stimulation and differential ability to up-regulate survival signals. Clin Exp Immunol 143:30. 2006.

Maletto BA, Rópolo AS, Liscovsky MV, Alignani DO, Glocker M, Pistoresi-Palencia MC. CpG oligodeoxinucleotides functions as an effective adjuvant in aged BALB/c mice. Clin Immunol. 117(3):251-61. 2005.

Alignani D, Maletto B, Liscovsky M, Rópolo A, Morón G, Pistoresi-Palencia MC. Orally administered OVA/CpG-ODN induces specific mucosal and systemic immune response in young and aged mice. J Leukoc Biol. 77(6):898-905. 2005.

Maletto B, Rópolo A, Morón V, Pistoresi-Palencia MC. “CpG-DNA stimulates cellular and humoral immunity and promotes Th1 differentiation in aged BALB/c mice”. J Leukoc Biol. 72(3):447-54. 2002.