Research projects

Molecular mechanisms involved in ocular inflammatory diseases:

  • Keratopathy environmental,
  • Glaucoma,
  • Retinopathy of prematurity.


ADMINISTRATION OF A PEPTIDE INHIBITOR OF ALPHA-Erro! Indicador não definido.4 INTEGRIN INHIBITS THE DEVELOPMENT OF EXPERIMENTAL AUTOIMMUNE UVEITIS. Andrea P. Martín, Luciana Vieira de Moraes, Carlos E. Tadokoro, Alessandra G. Commodaro, Enrique Urrets-Zavalia, Gabriel A. Rabinovich, Julio Urrets-Zavalia, Luiz V. Rizzo, Horacio M. Serra. IOVS 2005, 46:2056 -2063. ISSN: 0146-0404.

CLIMATIC DROPLET KERATOPATHY IN THE ARGENTINE PATAGONIA. Julio A. Urrets-Zavalía, Erna G. Knoll, J. Pablo Maccio, Enrique A. Urrets-Zavalía, José A. Saad, M.D. Horacio M. Serra, Am Journal Ophthalmology 2006, 141:744-746. ISSN: 0002-9394.

GALECTIN-1 SUPPRESSES AUTOIMMUNE RETINAL DISEASE BY PROMOTING CONCOMITANT T HELPER (TH)2- AND T REGULATORY-MEDIATED ANTI-INFLAMMATORY RESPONSES. Marta A. Toscano, Alessandra G. Commodaro, Germán A. Bianco, Juan M. Ilarregui, Ana Liberman,, Horacio M. Serra, Jun Hirabayashi, Luiz V. Rizzo and Gabriel A. Rabinovich.. J. Immunology 2006, 176: 6323–6332. ISSN: 0022-1767.

WHAT DO WE NEED TO LEARN TO OPTIMIZE THE SLIT ALTERNATIVE? Serra, H.M; Alignani, D.O; Passalacqua, G; Canonica, G.W; Correa, S.G. Allerg Immunol (Paris). 2006 May; 38(5):158-65. ISSN: 0397-9148 

SURFACE ALTERATIONS, CORNEAL HYPOESTHESIA AND IRIS ATROPHY IN PATIENTS WITH CLIMATIC DROPLET KERATOPATHY. Julio A. Urrets-Zavalia, J. Pablo Maccio, Erna G. Knoll, Thamara Cafaro, Enrique A. Urrets-Zavalia, Horacio M. Serra. Cornea, 2007; 26(7): 800-804. ISSN: 0277-3740.

PROTEOMIC ANALYSIS OF CLIMATIC KERATOPATHY DROPLETS. Michelle Menegay, DeMia Lee, Khalid F. Tabbara, Thamara A. Cafaro, Julio A. Urrets-Zavalía, Horacio M. Serra and Sanjoy K. Bhattacharya. IOVS, 2008; 49(7):2829-37. ISSN: 0146-0404.

THE CORNEA OF GUINEA PIG: STRUCTURAL AND FUNCTIONAL STUDIES. Thamara A. Cafaro, Susana G. Ortiz, Cristina Maldonado, Fernando A. Espósito, Juan O. Croxatto, Alejandro Berra, Omar L. Ale, Juan I. Torrealday, Enrique A. Urrets-Zavalía, Julio A. Urrets-Zavalía, Horacio M. Serra. Veterinary Ophthalmology. 2009, 12, 4, 234–24. ISSN: 1463-5216.

QUANTITATIVE ANALYSIS OF N-LINKED GLYCOPROTEINS IN TEAR FLUID OF CLIMATIC DROPLET KERATOPATHY BY GLYCOPEPTIDE CAPTURE AND ITRAQ. Lei Zhou, R. W. Beuerman, Ai Ping Chew, Siew Kwan Koh, TA Cafaro , EA Urrets-Zavalia, JA Urrets-Zavalia, SFY Li, HM Serra. J. Proteom. Res. 2009, 8 (4), pp 1992–2003. ISSN: 1535-3893.

PEPTIDYLARGININE DEIMINASE TYPE 2 IS OVER EXPRESSED IN THE GLAUCOMATOUS OPTIC NERVE. Thamara A. Cafaro, Stefanía Santo, Lucena A. Robles, Nicolás Crim, Julio A. Urrets-Zavalia, Horacio M. Serra. Molecular Vision. 2010, 16:1654-1658. ISSN: 1090-0535.

ALTERED EXPRESSION OF MATRIX METALLOPROTEASES AND THEIR TISSUE INHIBITORS AS POSSIBLE CONTRIBUTORS TO CORNEAL DROPLET FORMATION IN CLIMATIC DROPLET KERATOPATHY. Juha M. Holopainen, Horacio M. Serra, María C. Sánchez, Timo Sorsa, Waldir Neira Zalentein, Pablo F. Barcelona, Jukka A. O. Moilanen, Taina Tervahartiala, Timo M. T. Tervo, Thamara A. Cafaro, Ismo Virtanen, Enrique A. Urrets-Zavalia, Sanjoy K. Bhattacharya, Julio A. Urrets-Zavalia. Acta Ophthalmologica. 2011. 89:569-574. ISSN: 1755-375X.# The first two authors contributed equally to this work.

ORAL CAVITY-ASSOCIATED IMMUNE SYSTEM: WHAT IS NEW? Mirta Ana Valentich, Thamara Analía Cafaro, and Horacio Marcelo Serra. Current Immunology Review. 2011, 7:253-264. ISSN: 15733955

THE EFFECT OF VITAMIN C DEFICIENCY AND CHRONIC ULTRAVIOLET-B EXPOSURE ON CORNEAL ULTRASTRUCTURE: A PRELIMINARY INVESTIGATION. Sally Hayes, Thamara A Cafaro, Patricia Borkowska, Jon Harris, Christina Kamma-Lorger, Craig Boote, Robert Young, Jennifer Hiller, Nicholas Terrill, Keith M Meek, Horacio M Serra. Molecular Vision. 2011, 17:3107-3115. ISSN: 1090-0535. IN VIVO CONFOCAL LASER SCANNING MICROSCOPY STUDY OF CLIMATIC DROPLET KERATOPATHY. Julio A. Urrets-Zavalia, Juan O. Croxatto, Juha M. Holopainen, Thamara A. Cafaro, Fernando Esposito, Waldir Neira, Horacio M. Serra. Eye. 2012, 26, 1021-1023. PRO INFLAMMATORY CYTOKINES AND GELATINASES IN CLIMATIC DROPLET KERATOPATHY. Juha M. Holopainen, Alexandra Robciuc, Thamara A. Cafaro, Maria F. Suarez, Yrjö T. Konttinen,Khalid Tabbara, Taina Tervahartiala, Timo Sorsa, Julio A. Urrets-Zavalia, and Horacio M. Serra . IOVS, 2012; 53(7):3527-35. ISSN: 0146-0404.

IMPACT OF CHANGING OXYGENATION POLICIES ON RETINOPATHY OF PREMATURITY IN A NEONATAL UNIT IN ARGENTINA. Julio A. Urrets-Zavalia, Nicolas Crim, Erna G. Knoll, Fernando A. Esposito, Elizabeth Collino, Maria E. Urrets-Zavalia, Graciela Saenz-de-Tejada, Juan I. Torrealday, Horacio M. Serra, Clare Gilbert. Br J Ophthalmol 2013; 96:1456–1461. ISSN: 0007-1161. #The last two authors contributed equally to this work.

GENETIC BACKGROUND AND CLIMATIC DROPLET KERATOPATHY INCIDENCE IN A MAPUCHE POPULATION FROM ARGENTINA. Theodore G. Schurr , Matthew C. Dulik, Thamara A. Cafaro, María F. Suarez, Julio A. Urrets-Zavalia, Horacio M. Serra. PLOS ONE, September 2013 | Volume 8 | Issue 9 | e74593; eISSN-1932-6203

ALTERNARIA KERATITIS AND ENDOPHTALMITIS AFTER CLEAR-CORNEA PHAKOEMULSIFICATION. Julio A. Urrets-Zavalia, Juan-Pablo Maccio, Rodolfo Monti, Evangelina Esposito, Nicolas Crim, Marina Botiglieri, Laura Cervi, Horacio M. Serra. The Journal of Cataract & Refractive Surgery, 2014; 40:331–334 - ISSN: 08863350.

ON THE CORNEA OF HEALTHY MERINO SHEEP: A DETAILED EX-VIVO CONFOCAL, HISTOLOGICAL AND ULTRASTRUCTURAL STUDY. María F Suarez, Thamara A Cafaro, Cristina Maldonado, Juan O Croxatto, Constanza Insfrán, Julio A Urrets-Zavalía, Horacio M Serra. Anat Histol Embryol. 2014 Jul 17. doi: 10.1111/ahe.12131. ISSN: 1439-0264.

CLIMATIC DROPLET KERATOPATHY: AN OLD DISEASE IN NEW CLOTHES. Horacio M. Serra, Juha M. Holopainen, Roger Beuerman, Kai Kaarniranta, María.F Suárez, Julio A. Urrets-zavalia., ACTA OPHTHALMOLOGICA, 2015 JAN 28. DOI: 10.1111/AOS.12628. - ISSN: 1755-375X.

DEIMINATION LEVEL AND PEPTIDYL ARGININE DEIMINASE 2 EXPRESSION IS ELEVATED IN ASTROCYTES WITH INCREASED INCUBATION TEMPERATURE. Mabel Enriquez-Algeciras, Sanjoy K. Bhattacharya, Horacio M Serra. Journal of Neuroscience Research. 2015; 93:1388–1398. ISSN: 1097-4547.

SYSTEMIC AMYLOIDOSIS WITH BILATERAL CONJUNCTIVAL INVOLVEMENT: A CASE REPORT. Correa LJ, Maccio JP, Esposito E, Monti R, Gonzalez-Castellanos ME, Paradelo M, Serra HM, Urrets-Zavalia JA. BMC Ophthalmol. 2015 Jul 19; 15:77. doi:10.1186/s12886-015-0075-2. ISSN: 1471-2415.

CLIMATIC DROPLET KERATOPATHY IN ARGENTINA: INVOLVEMENT OF ENVIRONMENTAL AGENTS IN ITS GENESIS WHICH WOULD OPEN THE PROSPECT FOR NEW THERAPEUTIC INTERVENTIONS. Suárez María F Correa Leandro, Crim Nicolás Espósito Evangelina, Monti Rodolfo, Urrets-Zavalía Julio A, Serra Horacio M. BioMed Research International, 2015;2015:527835. doi: 10.1155/2015/527835. ISSN: 2314-6133.